GAS Reporter (Luc)-HeLa Cell Line (IFNγ/JAK/STAT1 Pathway)

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廠商性質：生產廠家
更新時間：2023-10-12
訪問量：244

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詳細介紹

數量：
1
供應商：
BPS Bioscience
細胞類型：
穩(wěn)轉細胞系
品系：
HeLa
組織來源：
/
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多種
物種來源：
human
免疫類型：
多種
器官來源：
無
運輸方式：
干冰
年限：
10
生長狀態(tài)：
良好
CAS號：
無
英文名：
GAS Reporter (Luc)-HeLa Cell Line (IFNγ/JAK/STAT1 Pathway)
注冊證號：
/
規(guī)格：
2管

The GAS reporter (Luc)-HeLa cell line is designed to monitor the activity of interferon gamma-induced signal transduction pathways in cultured cells by measuring activated STAT1 homodimers. It contains a firefly luciferase gene driven by three copies of the interferon gamma-activated sites (GAS) located upstream of the minimal TATA promoter. IFNγ first binds to a heterodimeric receptor consisting of two chains, IFNGR1 and IFNGR2, causing its dimerization and the activation of specific Janus family kinases (JAK1 and JAK2). Two STAT1 molecules associate with this ligand-activated receptor complex and are activated by phosphorylation to form active homodimer. The active STAT1 homodimers translocate to the nucleus where they bind interferon gamma-activated sites (GAS) in the promoter of IFNγ inducible genes, including luciferase reporter gene.

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GAS Reporter (Luc)-HeLa Cell Line (IFNγ/JAK/STAT1 Pathway)

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